Chapter Iv
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چکیده
Quorum sensing is a mechanism of interbacterial communication that has been shown to be involved in the regulation of several complex phenotypes and virulence in some pathogenic bacteria. In this chapter, the characterization of the luxS gene of H. somni as well as biofilm formation by different strains of H. somni are described. Based on the ability of the luxS gene from H. somni to complement autoinducer-2 biosynthesis in Escherichia coli DH5α, it is proposed that the gene encodes Sribosylhomocysteinase. It is shown that culture supernatants from different members of the Pasteurellaceae differ significantly in their ability to induce luminescence in V. harveyi strain BB170. Based on this evidence and in silico analyses of LuxP proteins, it is proposed that AI-2 is not an ‘universal signal’. It is also shown that several pathogenic isolates of H. somni form a prominent biofilm. A synthetic furanone has been shown to inhibit planktonic and biofilm growth of H. somni, raising the possibility that this molecule could potentially be used as an antibacterial agent. Preliminary results indicated that luxS as well as phosphorylcholine expression can influence biofilm formation by H. somni. However, further studies using H. somni mutants deficient in luxS and/or phosphorylcholine expression are required to verify these findings.
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تاریخ انتشار 2007